Profhilo H+L — Bio-Remodeling Injectable with 64mg Hybrid Hyaluronic Acid
Profhilo H+L is one of the most clinically significant innovations in aesthetic medicine in the past decade. Unlike any other injectable, it functions as a pure bio-remodeler — spreading through tissue via patented NAHYCO® Hybrid Technology to stimulate all four types of collagen and elastin simultaneously, while delivering intense, sustained hydration at every layer of the dermis.
What Is Profhilo H+L?
Developed by IBSA Derma (Italy), Profhilo H+L is a CE-certified Class III injectable tissue stimulator containing 64mg of hybrid hyaluronic acid (32mg H-HA + 32mg L-HA) per 2ml syringe — one of the highest HA concentrations of any injectable on the market. It contains no chemical cross-linking agents (BDDE-free), no parabens, and no anesthetics, making it exceptionally safe and well-tolerated.
Technology & Formula
- NAHYCO® Hybrid Technology — stable complex of high and low molecular weight HA
- 64mg HA per syringe (32mg H-HA + 32mg L-HA) — BDDE-free
- Not a filler — does not add volume; redistributes and stimulates biological activity
- CE-certified Class III medical device, manufactured in Switzerland
Key Features
- Stimulates type I, III, IV collagen + elastin — comprehensive tissue remodeling
- Bio-integration without volumization — natural result, no risk of over-filling
- 5-point BAP (Bio-Aesthetic Points) injection protocol — standardized for face and neck
- 2 sessions, 4 weeks apart = standard protocol for most patients
- Results visible 4–8 weeks after second session; duration 6–12 months with maintenance
Clinical Indications
Skin laxity and loss of firmness, dehydration, fine line improvement, overall skin quality rejuvenation. Most commonly used in the face, neck, décolleté, and hands. Particularly effective for patients with early-to-moderate aging signs who want quality improvement without volume change.
How to Use
Administer using the 5-point BAP protocol. 2ml per session, injected as bolus at 5 defined anatomical points per side. Standard protocol: 2 sessions 4 weeks apart, followed by 1 maintenance session every 6 months.
See also: Profhilo Structura (https://frayamedsupply.com/us/product/profhilo-structura) | Skin Boosters (https://frayamedsupply.com/us/category/skin-boosters) | Biostimulators (https://frayamedsupply.com/us/category/biostimulators)
Composition
- 32mg/ml of low molecular weight hyaluronic acid
- 32mg/ml of high molecular weight hyaluronic acid
- phosphate buffer pH 6.8–7.4 q.s.
- sodium chloride
Contains
- 1 x 2ml prefilled syringe
- 2 sterilized 29G1⁄2” needles
- Traceability labels
- Product leaflet
Profhilo H+L
1 x 2ml prefilled syringe
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Profhilo H+L — Bio-Remodeling Injectable with 64mg Hybrid Hyaluronic Acid
Profhilo H+L is one of the most clinically significant innovations in aesthetic medicine in the past decade. Unlike any other injectable, it functions as a pure bio-remodeler — spreading through tissue via patented NAHYCO® Hybrid Technology to stimulate all four types of collagen and elastin simultaneously, while delivering intense, sustained hydration at every layer of the dermis.
What Is Profhilo H+L?
Developed by IBSA Derma (Italy), Profhilo H+L is a CE-certified Class III injectable tissue stimulator containing 64mg of hybrid hyaluronic acid (32mg H-HA + 32mg L-HA) per 2ml syringe — one of the highest HA concentrations of any injectable on the market. It contains no chemical cross-linking agents (BDDE-free), no parabens, and no anesthetics, making it exceptionally safe and well-tolerated.
Technology & Formula
- NAHYCO® Hybrid Technology — stable complex of high and low molecular weight HA
- 64mg HA per syringe (32mg H-HA + 32mg L-HA) — BDDE-free
- Not a filler — does not add volume; redistributes and stimulates biological activity
- CE-certified Class III medical device, manufactured in Switzerland
Key Features
- Stimulates type I, III, IV collagen + elastin — comprehensive tissue remodeling
- Bio-integration without volumization — natural result, no risk of over-filling
- 5-point BAP (Bio-Aesthetic Points) injection protocol — standardized for face and neck
- 2 sessions, 4 weeks apart = standard protocol for most patients
- Results visible 4–8 weeks after second session; duration 6–12 months with maintenance
Clinical Indications
Skin laxity and loss of firmness, dehydration, fine line improvement, overall skin quality rejuvenation. Most commonly used in the face, neck, décolleté, and hands. Particularly effective for patients with early-to-moderate aging signs who want quality improvement without volume change.
How to Use
Administer using the 5-point BAP protocol. 2ml per session, injected as bolus at 5 defined anatomical points per side. Standard protocol: 2 sessions 4 weeks apart, followed by 1 maintenance session every 6 months.
See also: Profhilo Structura (https://frayamedsupply.com/us/product/profhilo-structura) | Skin Boosters (https://frayamedsupply.com/us/category/skin-boosters) | Biostimulators (https://frayamedsupply.com/us/category/biostimulators)
Composition
- 32mg/ml of low molecular weight hyaluronic acid
- 32mg/ml of high molecular weight hyaluronic acid
- phosphate buffer pH 6.8–7.4 q.s.
- sodium chloride
Contains
- 1 x 2ml prefilled syringe
- 2 sterilized 29G1⁄2” needles
- Traceability labels
- Product leaflet
Frequently Asked Questions
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