Nucleofill Medium — Polynucleotide (PDRN) Biostimulator for Skin Biorevitalization

Nucleofill Medium is a CE-certified injectable polynucleotide treatment that works at the biological level — stimulating cellular repair, fibroblast activation, and tissue regeneration through the regenerative properties of highly purified PDRN (polydeoxyribonucleotide).

What Is Nucleofill Medium?

Developed and manufactured in Italy, Nucleofill Medium contains 20mg/2ml of high-purity salmon PDRN — DNA fragments that stimulate A2A adenosine receptors in skin cells, triggering repair, collagen synthesis, and inflammatory control. Unlike HA-based injectables, polynucleotides improve tissue quality at a cellular level rather than through hydration or volumization.

Technology & Formula

• Polynucleotides (PDRN): 20mg/2ml — high-purity salmon DNA-derived
• Mechanism: A2A receptor activation → cellular repair, fibroblast stimulation, collagen synthesis
• CE-certified Class III medical device
• No HA — purely regenerative action

Key Features

• Biological regeneration rather than hydration-based improvement
• Stimulates collagen, elastin, and ECM components
• Anti-inflammatory properties — reduces oxidative stress in tissue
• CE-certified, Italian manufacture
• Suitable for face, neck, hands, and periorbital area

Clinical Indications

Skin biorevitalization, improvement of skin quality and hydration, early fine line correction, treatment of thin or photo-damaged skin, and periorbital rejuvenation. Also used in combination protocols with HA skin boosters or biostimulators.

How to Use

Multiple intradermal microinjections using 30G or 27G needle or microneedles. Standard protocol: 3–4 sessions, 2 weeks apart. Results are cumulative.

See also: Nucleofill Medium Plus Hair (https://frayamedsupply.com/us/product/nucleofill-medium-plus-hair) | Plinest (https://frayamedsupply.com/us/product/plinest) | Mesotherapy (https://frayamedsupply.com/us/category/mesotherapy)