Nucleofill Medium – Professional PN Tissue Stimulator for Skin Rejuvenation

Nucleofill Medium is a professional bio-stimulating injectable treatment based on 2% highly purified polynucleotides. Designed for deep hydration, skin regeneration, and anti-ageing effects, it helps improve elasticity, firmness, and overall skin quality. This tissue stimulator provides a lifting, antioxidant, and moisturising effect – making it a trusted choice for medical professionals looking to offer advanced rejuvenation therapies.

What Is Nucleofill Medium?

Nucleofill Medium is a  tissue stimulator formulated with 2% polynucleotides (25mg/1.5ml). Unlike hyaluronic acid fillers, it works through bio-restructuring and collagen stimulation rather than volume filling. Its unique mechanism targets fibroblast receptors, improving skin elasticity, hydration, and repair at a cellular level.

Professionals buy Nucleofill Medium as a reliable option for patients with dehydrated, lax, or ageing skin who need deep skin revitalisation without adding volume.

Indications for Nucleofill Medium Treatment

• Dehydrated or lax skin

• Fine lines and early wrinkles

• Reduced elasticity and tone

• Oxidative stress / skin exposed to UV/photoaging

• Atrophic scars and stretch marks

• Post-aesthetic procedure recovery

• Prevention of skin ageing

Nucleofill Medium Target Areas

• Face – improves elasticity, hydration, and tone

• Under-eye region – reduces fine lines & dark circles

• Jawline & cheeks – restores firmness and contour

• Neck & décolleté – reduces sagging and revitalises skin

• Hands – restores hydration and smoothness

• Body areas – effective for stretch marks & scars

Benefits and Results

• Deep hydration – long-lasting moisture retention

• Collagen & elastin stimulation – improved firmness

• Antioxidant protection – shields from oxidative stress

• Smoother texture – reduces fine lines & wrinkles

• Gradual lifting effect – progressive rejuvenation

• Safe & biocompatible – suitable for all skin types

Results last 6–12 months, with natural improvements visible after a few weeks.

Treatment Protocol

• Injection: dermis/subdermis using 30G needles

• Techniques: 5-point, linear retrograde, mesotherapy fan technique

• Protocol: 4 sessions every 2–4 weeks

• Maintenance: every 6–9 months

Possible Side Effects

Temporary redness, swelling, tenderness or mild bruising may occur. Rarely: infection, allergic reaction, or vascular complications.

Contraindications:

Pregnancy, breastfeeding, autoimmune disease, blood clotting disorders, active infection, hypersensitivity to ingredients.

Nucleofill Product Range at Fräya Med Supply

At Fräya Med Supply you can shop the complete Nucleofill range:

• Nucleofill Medium – for hydration, elasticity & anti-aging

• Nucleofill Soft Plus – hydration & fine line reduction, periorybital area

• Nucleofill 25 – advanced regeneration (formerly Strong)

• Nucleofill 20 – balanced rejuvenation formula

• Nucleofill Medium Plus Hair – advanced bio-stimulation for hair

 Also explore our Skin Boosters collection and Cannulas & Needles to complete your treatment protocols.

FAQ

How long does Nucleofill Medium last?

6–12 months, depending on skin type & lifestyle.

Is Nucleofill Medium the same as Nucleofill 25?

No – Medium contains 2% PN, while 25 contains 2.5% PN for stronger regeneration.

Profhilo vs Nucleofill – which is better?

Profhilo = hydration with HA. Nucleofill = regeneration with PN + antioxidant action.

Who can buy Nucleofill Medium?

Only licensed medical professionals, via authorised suppliers like Fräya Med Supply.