NEWEST One – PN-HPT™ + Hyaluronic Acid Biorevitalisation
Mastelli NEWEST One is a combined biorevitalisation treatment designed to support dermal regeneration and hydration. The formulation integrates PN-HPT™ polynucleotides, hyaluronic acid and mannitol, providing a balanced approach to skin quality improvement.
It is particularly suitable for patients requiring both biological stimulation and hydration support, especially in early to moderate stages of skin ageing.
KEY BENEFITS
- Combination of PN-HPT™ polynucleotides, hyaluronic acid and mannitol
- Supports fibroblast activity and dermal regeneration
- Improves hydration and skin elasticity
- Antioxidant support through mannitol
- Suitable for skin quality and pro-aging treatment protocols
HOW IT WORKS
Mastelli NEWEST One combines complementary mechanisms acting within the dermis:
PN-HPT™ polynucleotides
- support fibroblast activation
- contribute to collagen and extracellular matrix regeneration
- promote tissue repair processes
Hyaluronic acid (non-cross-linked)
- supports dermal hydration
- improves viscoelastic properties of the skin
- enhances extracellular environment
Mannitol
- acts as an antioxidant
- helps stabilise the dermal microenvironment
- supports longevity of the regenerative response
This combination results in progressive improvement of skin quality rather than volumetric correction.
INDICATIONS
- Early to moderate signs of skin ageing
- Dehydrated and dull skin
- Reduced elasticity
- Preventive (pro-aging / longevity protocols)
- Maintenance after more intensive treatments
PROTOCOL POSITIONING
Role in treatment protocols:
- Combined regeneration + hydration approach
- Entry-level or maintenance biorevitalisation
- Bridge between hydration-based therapies and pure biostimulation
- Suitable for patients not requiring strong regenerative stimulation
COMPARISON WITHIN POLYNUCLEOTIDE TREATMENTS
Mastelli NEWEST One belongs to a category of biorevitalisation products based on polynucleotides, but differs in formulation and clinical positioning.
|
Type of product |
Composition |
Primary role |
|---|---|---|
|
Pure polynucleotides (e.g. Nucleofill, Plinest) |
PN only |
Strong regenerative stimulation |
|
Combined PN formulations (e.g. NEWEST One) |
PN + hyaluronic acid + mannitol |
Balanced regeneration and hydration |
|
HA only |
Hydration and skin quality support |
NEWEST One is positioned as a balanced solution for patients requiring both dermal regeneration and hydration support.
PRODUCT SPECIFICATION
- Form: solution
- Components: PN-HPT™ polynucleotides, hyaluronic acid, mannitol
- Administration: intradermal
- Treatment areas: face, neck, décolleté, hands
- Packaging: ampoules
- Manufacturer: Mastelli Srl (Italy)
- Regulatory status: CE-marked medical device
COMPLIANCE
This product is a CE-marked medical device intended for use by qualified healthcare professionals.
It should be administered in accordance with applicable regulations and clinical practice guidelines.
Composition
- Polynucleotides (PN-HPT®): 1 mg/ml
- Non-crosslinked hyaluronic acid: 1 mg/ml
- Mannitol
Contains
5 x 4 ml
NEWEST One
5 x 4ml
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For professional use only. Purchase confirms appropriate training and qualifications
NEWEST One – PN-HPT™ + Hyaluronic Acid Biorevitalisation
Mastelli NEWEST One is a combined biorevitalisation treatment designed to support dermal regeneration and hydration. The formulation integrates PN-HPT™ polynucleotides, hyaluronic acid and mannitol, providing a balanced approach to skin quality improvement.
It is particularly suitable for patients requiring both biological stimulation and hydration support, especially in early to moderate stages of skin ageing.
KEY BENEFITS
- Combination of PN-HPT™ polynucleotides, hyaluronic acid and mannitol
- Supports fibroblast activity and dermal regeneration
- Improves hydration and skin elasticity
- Antioxidant support through mannitol
- Suitable for skin quality and pro-aging treatment protocols
HOW IT WORKS
Mastelli NEWEST One combines complementary mechanisms acting within the dermis:
PN-HPT™ polynucleotides
- support fibroblast activation
- contribute to collagen and extracellular matrix regeneration
- promote tissue repair processes
Hyaluronic acid (non-cross-linked)
- supports dermal hydration
- improves viscoelastic properties of the skin
- enhances extracellular environment
Mannitol
- acts as an antioxidant
- helps stabilise the dermal microenvironment
- supports longevity of the regenerative response
This combination results in progressive improvement of skin quality rather than volumetric correction.
INDICATIONS
- Early to moderate signs of skin ageing
- Dehydrated and dull skin
- Reduced elasticity
- Preventive (pro-aging / longevity protocols)
- Maintenance after more intensive treatments
PROTOCOL POSITIONING
Role in treatment protocols:
- Combined regeneration + hydration approach
- Entry-level or maintenance biorevitalisation
- Bridge between hydration-based therapies and pure biostimulation
- Suitable for patients not requiring strong regenerative stimulation
COMPARISON WITHIN POLYNUCLEOTIDE TREATMENTS
Mastelli NEWEST One belongs to a category of biorevitalisation products based on polynucleotides, but differs in formulation and clinical positioning.
|
Type of product |
Composition |
Primary role |
|---|---|---|
|
Pure polynucleotides (e.g. Nucleofill, Plinest) |
PN only |
Strong regenerative stimulation |
|
Combined PN formulations (e.g. NEWEST One) |
PN + hyaluronic acid + mannitol |
Balanced regeneration and hydration |
|
HA only |
Hydration and skin quality support |
NEWEST One is positioned as a balanced solution for patients requiring both dermal regeneration and hydration support.
PRODUCT SPECIFICATION
- Form: solution
- Components: PN-HPT™ polynucleotides, hyaluronic acid, mannitol
- Administration: intradermal
- Treatment areas: face, neck, décolleté, hands
- Packaging: ampoules
- Manufacturer: Mastelli Srl (Italy)
- Regulatory status: CE-marked medical device
This product is a CE-marked medical device intended for use by qualified healthcare professionals. It should be administered in accordance with applicable regulations and clinical practice guidelines.
Composition
- Polynucleotides (PN-HPT®): 1 mg/ml
- Non-crosslinked hyaluronic acid: 1 mg/ml
- Mannitol
Contains
5 x 4 ml
FAQ -Mastelli NEWEST One
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