What Is Rejuran?
Rejuran is PharmaResearch’s established range of salmon-derived polynucleotide (PN) injectables intended for facial wrinkle and skin quality indications. The purified PN fraction is administered intradermally, with product selection determined by the treatment area and the formulation-specific indication.
What Rejuran does not contain is as defining as what it does. No calcium hydroxylapatite, no poly-L-lactic acid, no cross-linked gel. The formulations are not intended for structural volumisation or contour correction, placing Rejuran in a distinct category from dermal fillers.
The Rejuran products currently available at Fräya include three formulations, each directed at a different tissue problem. Choosing between them is an indication decision, not a strength decision.
Why Practitioners Choose Rejuran
Rejuran is one of the most widely recognised names in the injectable polynucleotide category. It is developed and manufactured by PharmaResearch, a company whose work in polynucleotide chemistry preceded the aesthetic application, and the range is supplied across international markets.
The portfolio is built around indication-specific formulations rather than a single product intended for every treatment area. Full-face, periorbital and hybrid formats sit within one brand, which allows a practice to build protocols across different tissue types without moving between manufacturers.
Production is based on DOT™, PharmaResearch’s proprietary DNA optimising technology, which underpins the brand’s technical identity within the category.
Rejuran Product Range
| Product | Composition | Volume | Best suited for |
|---|---|---|---|
| Rejuran Rejuvenation with PN | PN formulation | 2 ml | Full face, neck, décolleté, hands – large treatment fields and general dermal quality loss |
| Rejuran I | PN formulation, low viscosity | 1 ml | Periorbital area – thin, mobile eyelid skin and crepey texture |
| Rejuran HB Plus | PN + hyaluronic acid + lidocaine | 1 ml | Dehydrated, dull skin where hydration and regeneration are both objectives |
Each formulation is designed for a different treatment objective, allowing practitioners to select the most appropriate product according to the treatment area, tissue characteristics and clinical indication.
The manufacturer’s wider line includes further formulations, among them a high-viscosity product developed for atrophic scarring, supplied in selected markets. Composition, concentration and pack format should be confirmed against the labelling and Instructions for Use supplied with the specific product and market.
Rejuran I exists because the periorbital dermis behaves unlike anywhere else on the face: thin, mobile and unforgiving of superficial placement. Its lower-viscosity formulation is designed for controlled intradermal placement in thin periorbital skin. Rejuran HB Plus addresses a different requirement. It combines the polynucleotide fraction with hyaluronic acid, and it contains lidocaine, which according to the manufacturer is intended to reduce procedural discomfort.
DOT™ – The Rejuran Manufacturing Platform
Injectable polynucleotide products are prepared from purified DNA fractions obtained from salmonid fish. What differs between brands is the process used to extract and prepare that material, and this is where Rejuran’s technical identity sits.
DOT™ (DNA Optimizing Technology) is PharmaResearch’s proprietary technology for extracting and optimising salmon-derived DNA for use as a regenerative material. It is a defining element of the Rejuran manufacturing platform and applies across the range rather than to a single formulation.
In December 2024, PharmaResearch announced EU MDR certification for Rejuran, Rejuran I and Rejuran S. The regulatory status of each formulation should be confirmed for the specific product and destination market.
What Is Rejuran Used For?
Rejuran is used where the presenting problem is the quality of the skin rather than its volume or contour.
- Thin, dehydrated or photodamaged skin on the face, neck and décolleté
- Fine surface lines, crepiness and loss of elasticity
- Enlarged pores and uneven skin texture
- Periorbital skin quality, including crepey texture and translucency contributing to visible shadowing
Polynucleotide injectables are also discussed in the literature and in clinical practice as part of selected sequential protocols around energy-based procedures. This should not be interpreted as a universal product indication, and timing should follow the product-specific Instructions for Use.
Rejuran is not a substitute for volumetric correction. Contour deficit, structural laxity and hollowing driven by fat compartment loss are outside the scope of the range and belong in
HA filler protocols
or, where diffuse deep collagen deficit is the issue, in a course from the
biostimulator category
. Where multiple injectable classes are planned, sequential treatment may make assessment of outcomes and adverse events clearer; timing should follow the relevant Instructions for Use and the individual treatment plan.
How Rejuran Compares with Other Polynucleotide Brands
Several polynucleotide families are available within the
skin booster
range. They share an active class and differ in DNA source, preparation technology, concentration, rheology and product-specific indications.
| Brand | DNA source | Main product focus |
|---|---|---|
| Rejuran | Salmon | Multiple indication-specific formulations |
| Nucleofill | Salmon | Pure PN formulations |
| Croma PolyPhil | Trout | PN and hybrid formulations |
Polynucleotide families share overlapping biological principles but differ in the parameters above, and should not be treated as functionally interchangeable on the basis of a shared active class. Rejuran is also distinct from hyaluronic acid fillers: the formulations are not intended for structural volumisation or contour correction. The mechanistic comparison of the class, including the distinction from PDRN, is set out in the
polynucleotides and PDRN guide
.
Who Is the Manufacturer of Rejuran?
Rejuran is manufactured by PharmaResearch Co., Ltd., a South Korean company active in regenerative medicine. Its research background is in polydeoxyribonucleotide and polynucleotide chemistry for tissue repair, and the aesthetic range grew out of that platform rather than being developed as a standalone cosmetic product.
Rejuran injectable formulations are supplied as medical devices in authorised markets. Regulatory status and authorised use should be verified for the individual SKU and destination market, and the Instructions for Use reviewed before treatment, as injection depth, technique and volume differ between formulations.
What Are the Main Ingredients of Rejuran?
The active across the range is a purified polynucleotide fraction obtained from salmon DNA.
The pure polynucleotide formulations contain no hyaluronic acid. Rejuran HB Plus is the exception, combining the polynucleotide fraction with hyaluronic acid and lidocaine hydrochloride. Review the patient’s history of hypersensitivity to lidocaine or other amide-type local anaesthetics when using HB Plus.
Expected Treatment Outcomes
Changes develop progressively rather than immediately. The core PN formulations are not intended to provide same-day structural correction; Rejuran HB Plus may provide an earlier hydration effect due to its hyaluronic acid component.
Expected treatment outcomes include improvements in skin texture, elasticity, hydration and the appearance of fine lines. Changes in texture, hydration and elasticity may develop at different stages of the treatment course and should be assessed after completion of the recommended protocol.
Outcomes after an incomplete course may not reflect the expected result of the full treatment protocol.
How Long Does Rejuran Last?
Treatment protocols and maintenance intervals vary between Rejuran formulations. Maintenance intervals may differ between pure PN and hybrid formulations and should be based on the product-specific protocol, treatment response and individual patient assessment.
Who Can Buy Rejuran
Products available on frayamedsupply.com are intended for use by trained and licensed medical professionals authorised to perform aesthetic injectable treatments in accordance with applicable local regulations. They are not consumer products.
The Rejuran formulations listed above are ordered from their individual product pages, where composition, pack format and current availability are stated for each item.
FAQ
What is Rejuran?
Rejuran is a brand of injectable polynucleotide (PN) products developed by PharmaResearch. The range covers several formulations, each intended for a different facial wrinkle or skin quality indication.
Who manufactures Rejuran?
PharmaResearch Co., Ltd., a South Korean company active in regenerative medicine, with a research background in polydeoxyribonucleotide and polynucleotide chemistry for tissue repair.
What makes Rejuran different from other polynucleotide brands?
Rejuran is produced using DOT™, PharmaResearch’s proprietary DNA optimising technology, and the range covers full-face, periorbital and hybrid formulations within a single brand rather than a single formulation.
Is Rejuran a dermal filler?
No. Rejuran contains no cross-linked gel, and the formulations are not intended for structural volumisation or contour correction. It is positioned separately from products used for volume and contour.
Who can purchase Rejuran products?
Products available on frayamedsupply.com are intended for use by trained and licensed medical professionals authorised to perform aesthetic injectable treatments in accordance with applicable local regulations.
