Newest® by Mastelli — Polynucleotide and Hyaluronic Acid Injectables
Newest® by Mastelli is a polynucleotide and hyaluronic acid injectable designed for intradermal skin regeneration and hydration, used when both dermal repair and moisture support are required within one treatment protocol. Newest® is typically used when patients present with both dehydration and reduced skin quality, where HA alone would be insufficient.
✔ Available for verified aesthetic practitioners ✔ CE-marked PN + HA injectable ✔ Fast EU-wide delivery
What Is Newest®?
Polynucleotide-based injectables are used in aesthetic medicine to support skin regeneration, improve dermal structure, and enhance overall skin quality. Newest® is a CE-marked injectable medical device by Mastelli (Italy) combining polynucleotides derived from highly purified trout DNA with non-cross-linked hyaluronic acid.
The PN fraction acts at the cellular level — interacting with fibroblast receptors to support fibroblast activity, promote extracellular matrix remodelling, and support endogenous collagen synthesis. The HA fraction provides immediate intradermal hydration and creates a favourable environment for tissue regeneration. This positions Newest® within modern skin quality and longevity-focused aesthetic protocols.
This dual-mechanism approach differentiates Newest® from standalone
Skin Boosters (hydration-focused) and from pure biostimulators (collagen-induction only). It is designed for practitioners who want to address skin quality, elasticity, and hydration within a single treatment session.
Newest® vs HA Skin Boosters vs Plinest®
| Product | Active components | Primary mechanism |
|---|---|---|
| Newest® | PN + HA | Regeneration + hydration |
| HA Skin Boosters | HA only | Intradermal hydration |
| Plinest® | PN only | Biostimulation + regeneration |
Clinical Applications
Newest® is indicated for:
- Skin laxity and loss of dermal density — face, neck, and décolletage
- Fine lines and superficial wrinkles on thin or photodamaged skin
- Skin quality maintenance and preventive biorevitalisation protocols
- Combination use alongside volumising fillers or energy-based devices where skin quality is the primary concern
The product is suitable for a range of skin types and ages. Its PN component is particularly relevant in protocols targeting patients with early signs of dermal ageing, where support of the fibroblast repair cascade is the therapeutic priority.
When to Choose Newest® Over HA Skin Boosters?
Newest® is selected when hydration alone is insufficient and dermal regeneration is required. Compared to HA-only Skin Boosters, it is more suitable for:
- Patients with reduced skin density and elasticity where HA hydration alone would be inadequate
- Post-procedural recovery protocols requiring tissue support alongside hydration
- Early dermal ageing presenting with both dehydration and loss of dermal resilience
- Combination treatments with volumising fillers or energy-based devices where skin quality is the concurrent objective
For practitioners already working with HA Skin Boosters, Newest® represents a logical step up when the clinical picture calls for active cellular regeneration alongside hydration.
Newest® Within the Mastelli Portfolio
Mastelli (Italy) produces two core PN-based lines available at Fräya Med Supply:
Plinest® — polynucleotides only; pure biostimulatory action targeting collagen induction and tissue regeneration without the HA component.
Newest® — polynucleotides combined with hyaluronic acid; addresses both biostimulation and intradermal hydration in a single formulation.
For practitioners already using Plinest®, Newest® offers a complementary option where hydration support is a treatment objective alongside cellular regeneration.
Why Practitioners Choose Newest®
The shift toward skin quality over volume has made combination PN+HA products increasingly relevant in everyday practice. Newest® answers a specific clinical need: patients who present with both dehydration and reduced skin resilience — a combination common in patients over 35, in photodamaged skin, and increasingly in patients experiencing volume loss secondary to GLP-1 medication use, where facial skin quality becomes a primary concern independent of structural volume.
Mastelli’s manufacturing process for polynucleotide extraction is focused on high purity and biocompatibility, reducing the risk of inflammatory response — a relevant consideration for practitioners working with sensitive or reactive skin types. Available through Fräya Med Supply with verified sourcing and fast EU distribution.
Order Newest® at Fräya Med Supply
Fräya Med Supply supplies Newest® to licensed aesthetic medicine practitioners across Europe, including Italy, Spain, Romania, Bulgaria, Hungary, and Ireland. Orders are processed within 24 hours with delivery typically within 1–5 business days across the EU. Trusted by clinics across Europe for consistent supply and product authenticity.
Browse the full Newest® range or explore complementary products in our Skin Boosters and Biostimulators categories.
Key Takeaways
- Newest® by Mastelli (Italy) is a polynucleotide and hyaluronic acid injectable for intradermal skin regeneration and hydration
- Indicated for the face, neck, and décolletage; selected when both dermal repair and hydration are required in one protocol
- PN fraction supports fibroblast activity and extracellular matrix remodelling; HA fraction delivers immediate intradermal hydration
- Distinct from HA-only Skin Boosters (hydration) and Plinest® (PN-only biostimulation)
- CE-certified under MDR 2017/745; available for licensed practitioners via Fräya Med Supply
FAQ
What is Newest® used for? Newest® by Mastelli (Italy) is a polynucleotide and hyaluronic acid injectable indicated for intradermal treatment of the face, neck, and décolletage. It supports dermal hydration, fibroblast activity, and collagen synthesis — used when skin quality concerns require both regenerative and hydrating action within one protocol.
How does Newest® differ from Plinest®? Both products are made by Mastelli (Italy) and use purified polynucleotides, but Plinest® contains polynucleotides only, targeting biostimulation and tissue regeneration. Newest® adds hyaluronic acid, making it the appropriate choice when intradermal hydration is required alongside regenerative action.
When should Newest® be chosen over an HA skin booster? Newest® is best used when patients present with both dehydration and reduced skin quality — where HA alone would be insufficient. Its polynucleotide component supports cellular repair and extracellular matrix remodelling beyond what hydration-only products can achieve.
Is Newest® a dermal filler or a skin booster? Neither exclusively. Newest® is a hybrid injectable combining PN-driven biostimulatory effects with HA-based intradermal hydration. It is not a volumising filler and does not provide structural lift or contouring.
Is Newest® CE-certified? Yes. Newest® is a CE-marked medical device compliant with MDR 2017/745, indicated for professional use by licensed aesthetic medicine practitioners.
